Turmeric, scientifically known as Curcuma longa, is a vibrant golden spice that has been an integral part of culinary and medicinal traditions for centuries.
Originating from the Indian subcontinent, this golden spice is a member of the ginger family and is renowned for its warm, earthy flavour and distinctive yellow hue.
Sites | Constituents | Anticancer Effects |
Lung | Curcumin | Inducing apoptosis (programmed cell death, a natural and controlled process) and DNA damage; inhibiting proliferation, migration, and |
Liver | Curcumin | Inhibiting the growth of hepatoma cells (hepatocellular carcinoma (HCC) cells / cancerous cells), inhibiting and reversing |
Breast | Curcumin | Inhibiting MCF-7 (a specific human breast cancer cell) breast carcinoma cells, cell invasion, and sensitizing |
Stomach | Curcumin | Inhibiting proliferation and invasion, promoting apoptosis, suppressing |
Colorectum | Curcumin | Preventing aberrant crypt foci, inducing apoptosis, inhibiting cell growth |
Cervix | Curcumin | Eradicating HPV+ cancer cells without affecting non-cancerous tissue, |
Prostate | Curcumin | Targeting AR and histone modification, inhibiting the proliferation and |
Turmeric has garnered significant attention for its potential anti-cancer properties, primarily attributed to its active compound, curcumin. Numerous studies suggest that curcumin possesses anti-inflammatory and antioxidant characteristics, which may play a role in preventing and combating cancer.
Curcumin has been investigated for its ability to inhibit cancer cell growth and impede tumour development. Additionally, it may interfere with various signalling pathways involved in cancer progression.
The below table1Â summarises the scientific findings of the curcumin compound which is responsible for most of the anti-cancer properties.
Limitations of Turmeric in Cancer Treatment
Despite its potential use in cancer treatment, one major limitation of this spice (curcumin) is its poor bioavailability, which hinders its therapeutic efficacy.
Efforts have been made to improve its bioavailability, such as using adjuvant phytochemicals found in turmeric itself.
Additionally, curcumin can modulate the function of drug-metabolizing enzymes and drug transporters, which may affect the pharmacokinetics of other drugs.
Increasing the bioavailability of Curcumin
Curcumin is a compound with poor bioavailability due to its low solubility and quick elimination from the body. Several approaches have been explored to enhance its bioavailability.
One approach is the use of solid dispersion systems, where curcumin is dispersed in smaller particle sizes. Studies have shown that decreasing the particle size of curcumin solid dispersions improves its bioavailability and solubility in micelles2Â .
Another approach is the derivatization of curcumin with isoleucine, which has been found to increase the bioavailability of curcumin in plasma and reproductive organs3.
Studies have shown that combining curcumin with piperine, a compound found in black pepper, can significantly improve its bioavailability4. Piperine can modulate metabolic enzymes and drug transporters, enhancing the absorption and utilization of curcumin in the body 5.
Typically, turmeric contains about 2-5% curcumin by weight. If you’re considering curcumin supplements, dosages often range from 500 to 2,000 milligrams per day, but individual needs may differ. It’s crucial to follow the product-specific recommendations and consult with a healthcare provider, especially if you have pre-existing health conditions or are taking medications.
The inclusion of turmeric in one’s diet is highly recommended for its potential in supporting and possibly preventing cancer. Curcumin, the active compound in turmeric, has demonstrated promising anti-cancer properties in various studies.
Its ability to modulate inflammation, inhibit tumor growth, and induce apoptosis in cancer cells makes it a compelling dietary addition.
While more research is needed, incorporating turmeric into a balanced diet serves as a proactive and delicious approach to potentially bolstering the body’s defenses against cancer and supporting overall health.
Is turmeric safe to consume?
Turmeric is generally considered safe and is used as a spice in food. It has been consumed for centuries in various cultures without significant adverse effects..
What is the safe dosage for curcumin supplements?
There is no established Recommended Dietary Allowance (RDA) for curcumin, and optimal dosages can vary. Typically 500mg to 1500mg per day is suggested. It is essential to consult with a healthcare professional.
