Increasing the bioavailability of Curcumin

Curcumin is a compound with poor bioavailability due to its low solubility and quick elimination from the body. Several approaches have been explored to enhance its bioavailability.

One approach is the use of solid dispersion systems, where curcumin is dispersed in smaller particle sizes. Studies have shown that decreasing the particle size of curcumin solid dispersions improves its bioavailability and solubility in micelles² .

Another approach is the derivatization of curcumin with isoleucine, which has been found to increase the bioavailability of curcumin in plasma and reproductive organs³.

Studies have shown that combining curcumin with piperine, a compound found in black pepper, can significantly improve its bioavailability⁴. Piperine can modulate metabolic enzymes and drug transporters, enhancing the absorption and utilization of curcumin in the body ⁵.